RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Open Access
- 1 August 1996
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 382 (6593) , 685-691
- https://doi.org/10.1038/382685a0
Abstract
Amyloid-beta peptide is central to the pathology of Alzheimer's disease, because it is neurotoxic—directly by inducing oxidant stress, and indirectly by activating microglia. A specific cell-surface acceptor site that could focus its effects on target cells has been postulated but not identified. Here we present evidence that the 'receptor for advanced glycation end products' (RAGE) is such a receptor, and that it mediates effects of the peptide on neurons and microglia. Increased expression of RAGE in Alzheimer's disease brain indicates that it is relevant to the pathogenesis of neuronal dysfunction and death.Keywords
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