Imaging Mass Spectrometry for the Assessment of Drugs and Metabolites in Tissue
- 1 May 2009
- journal article
- review article
- Published by Taylor & Francis in Bioanalysis
- Vol. 1 (2) , 309-319
- https://doi.org/10.4155/bio.09.33
Abstract
The study of drug distribution within biological tissue is a key part of the development of new pharmaceuticals. Matrix-assisted laser desorption ionization-mass spectrometric imaging is a powerful new imaging technique that can be used to study the distribution of a diverse range of endogenous and xenobiotic compounds within biological tissue. Here, fundamental aspects of the technique, appropriate instrumentation and applications in the study of xenobiotics and metabolite distribution are described. Sample preparation issues and some of the challenges in data interpretation/handling are also discussed.Keywords
This publication has 43 references indexed in Scilit:
- IMS/MS: its time has comeAnalytical Chemistry, 2008
- C60 Secondary Ion Mass Spectrometry with a Hybrid-Quadrupole Orthogonal Time-of-Flight Mass SpectrometerAnalytical Chemistry, 2008
- A high‐resolution scanning microprobe matrix‐assisted laser desorption/ionization ion source for imaging analysis on an ion trap/Fourier transform ion cyclotron resonance mass spectrometerRapid Communications in Mass Spectrometry, 2008
- MALDI-FTICR Imaging Mass Spectrometry of Drugs and Metabolites in TissueAnalytical Chemistry, 2008
- MALDI‐ion mobility‐TOFMS imaging of lipids in rat brain tissueJournal of Mass Spectrometry, 2007
- Solid Ionic Matrixes for Direct Tissue Analysis and MALDI ImagingAnalytical Chemistry, 2006
- Determination of pharmaceutical compounds in skin by imaging matrix‐assisted laser desorption/ionisation mass spectrometryRapid Communications in Mass Spectrometry, 2004
- Integrating Histology and Imaging Mass SpectrometryAnalytical Chemistry, 2004
- Direct tissue analysis using matrix‐assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparationJournal of Mass Spectrometry, 2003
- Protein and polymer analyses up to m/z 100 000 by laser ionization time‐of‐flight mass spectrometryRapid Communications in Mass Spectrometry, 1988