Expression of hypoxia inducible factor-1α and its relationship to apoptosis and proliferation in human laryngeal squamous cell carcinoma
- 1 December 2004
- journal article
- Published by Springer Nature in Journal of Huazhong University of Science and Technology [Medical Sciences]
- Vol. 24 (6) , 636-638
- https://doi.org/10.1007/bf02911379
Abstract
To investigate the expression of hypoxia inducible factor-1 alpha (HIF-1α) and its relationship to apoptosis and proliferation in laryngeal squamous cell carcinoma (LSCC), immunohistochemical method was used to detect the expression of HIF-1α and PCNA. Tunnel technique was used to detectin situ cell apoptosis in LSCC. Our results showed that the expression of HIF-1α was related to the clinical stages of cancer and lymph node metastasis (PP0.05) It is concluded that HIF-1α plays a role in the carcinogenesis of laryngeal carcinoma and is correlated with proliferation, but bears no relationship with the apoptosis of tumor cells in LSCC.Keywords
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