Immunoreactive cytokeratins in plasmacytomas

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Abstract
Fourteen plasma cell tumors, including examples of solitary plasmacytoma and multiple myeloma, were studied with a panel of antibodies reactive in formalin-fixed, paraffin wax-embedded tissue. Each case showed immunoglobulin light chain restriction. Five tumors were reactive with antibodies to cytokeratin. Of these five cases, four were negative with antibodies to leucocyte common antigen and only one was weakly positive. Anti-cytokeratin reactivity by plasma cell tumors is more common than was originally anticipated and represents an important diagnostic pitfall.