In Vitro Effects of Albendazole Sulfoxide and Praziquantel against Taenia solium and Taenia crassiceps Cysts

Open Access

1 June 2004

journal article
research article
Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy

Vol. 48 (6) , 2302-2304
https://doi.org/10.1128/aac.48.6.2302-2304.2004

Abstract

We investigated the minimum exposure times of prazicuantel (PZQ) and albendazole sulfoxide (ABZSO) required for their activities against Taenia cysts in vitro as well as the 50 and 99% effective concentrations. The results showed that although the effects of both drugs are time and concentration dependent, ABZSO acts much slower and is less potent than PZQ.

Keywords

This publication has 8 references indexed in Scilit:

Mode of action of benzimidazoles
Published by Elsevier ,2003
In vitro effect of praziquantel and albendazole combination therapy on the larval stage of Echinococcus granulosus
Zeitschrift Fur Parasitenkunde-Parasitology Research, 2000
Efficacies of Albendazole Sulfoxide and Albendazole Sulfone against In Vitro-Cultivated Echinococcus multilocularis Metacestodes
Antimicrobial Agents and Chemotherapy, 1999
Development of a chemotherapeutic model for the in vitro screening of drugs against Echinococcus granulosus cysts: the effects of an albendazole-albendazole sulphoxide combination
International Journal for Parasitology, 1996
Time course of the effect of praziquantel onSchistosoma mansoni attachment in vitro: comparison with its effects on worm length and motility
Zeitschrift Fur Parasitenkunde-Parasitology Research, 1995
The effects of albendazole and albendazole sulphoxide combination-therapy on Echinococcus granulosus in vitro
International Journal for Parasitology, 1994
In vitro culture of Echinococcus multilocularis: protoscolicidal action of praziquantel and albendazole sulphoxide
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988
Effect of albendazole sulphoxide on viability of hydatid protoscoleces in vitro
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1986