FACTOR IN HUMAN SALIVA THAT INDUCES DIFFERENTIATION OF MOUSE MYELOID-LEUKEMIA CELLS
- 1 January 1978
- journal article
- research article
- Vol. 38 (1) , 103-109
Abstract
The differentiated functions of phagocytosis, locomotion and morphological changes into cells resembling granulocytes and macrophages were induced in cultured mouse myeloid leukemic cells, M1 clone 34, by treatment with human saliva. The rates of induction of these differentiated phenotypes were proportional to the concentration of saliva added and period of treatment. The factor inducing differentiation was nondialyzable and heat labile. This factor was purified 70-fold by fractionation with Diaflo membranes and DE52 column chromatography. The activities inducing the 3 differentiated characters examined were purified together, suggesting that they were all due to the same factor.This publication has 2 references indexed in Scilit:
- Nerve growth factor receptors on human melanoma cells in culture.Proceedings of the National Academy of Sciences, 1977
- Isolation of a Mouse Submaxillary Gland Protein Accelerating Incisor Eruption and Eyelid Opening in the New-born AnimalJournal of Biological Chemistry, 1962