“Battered data”-Some clinical effects of the abuse of multiple regression methods: A second look at some observations on Ro07−0582 (Misonidazole)

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Abstract
An argument was presented for the wider use of simple and standard statistical methods in the design and evaluation of laboratory and clinical [human cancer radiotherapy] experiments with toxic radiosensitizers. An argument was presented against the frequent practice of superposing a curve estimated from laboratory observations upon scattergrams of clinical observations to thereby assist the reader to the (often fallacious) inference that the 2 disparate sets of observations have enough in common to be graduated by the same curve. Such a practice achieves a substitution of reasoning by analogy for the more reliable statistical procedures of estimation and of testing a hypothesis.