Bradyrhizobium japonicum FixK 2 , a Crucial Distributor in the FixLJ-Dependent Regulatory Cascade for Control of Genes Inducible by Low Oxygen Levels
- 1 October 1998
- journal article
- research article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 180 (19) , 5251-5255
- https://doi.org/10.1128/jb.180.19.5251-5255.1998
Abstract
Bradyrhizobium japonicum possesses a second fixK -like gene, fixK 2 , in addition to the previously identified fixK 1 gene. The expression of both genes depends in a hierarchical fashion on the low-oxygen-responsive two-component regulatory system FixLJ, whereby FixJ first activates fixK 2 , whose product then activates fixK 1 . While the target genes for control by FixK 1 are unknown, there is evidence for activation of the fixNOQP , fixGHIS , and rpoN 1 genes and some heme biosynthesis and nitrate respiration genes by FixK 2 . FixK 2 also regulates its own structural gene, directly or indirectly, in a negative way.Keywords
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