Mesonephroid (clear cell) carcinoma of the ovary and endometrium.A comparative prospective clinico-pathological study and review of literature

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Abstract
Seventeen cases of mesonephroid (clear cell) primary ovarian adenocarcinoma together with 6 cases of its analogous endometrial tumor have been studied over the decade ending 1976. Eleven of the ovarian tumors and all six of the endometrial tumors formed part of a personal consecutive series of 64 primary ovarian carcinomas and 114 primary endometrial carcinomas seen during the same period, these cases being studied prospectively. The remaining 6 ovarian tumors were studied retrospectively. Aims were to reexamine evidence for considering these tumors as distinct and homogenous groups; to reexamine evidence regarding their histogenesis; to investigate the concordance between the ovarian and endometrial tumor; and to reexamine clinical, pathological, therapeutic, and survival data relevant to these tumors. Full clinical, pathological, therapeutic, and survival details are recorded. It is suggested that present evidence indicates complete compatibility between the three major current views regarding histogenesis of the ovarian tumors; that in only a small proportion of cases is there histogenic coincidence between the ovarian and endometrial lesions; and that, pending further investigation, separation of the endometrial clear cell carcinomas from other nonclear endometrial carcinomas should be on a provisional basis only. Suggestions are made for further investigations into the prognostic aspects of these tumors.

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