Mapping quantitative trait loci in humans: achievements and limitations
Open Access
- 1 June 2005
- journal article
- review article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 115 (6) , 1419-1424
- https://doi.org/10.1172/jci24757
Abstract
Recent advances in statistical methods and genomic technologies have ushered in a new era in mapping clinically important quantitative traits. However, many refinements and novel statistical approaches are required to enable greater successes in this mapping. The possible impact of recent findings pertaining to the structure of the human genome on efforts to map quantitative traits is yet unclear.Keywords
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