Is G2-arrest an Active Cellular Response to Irradiation?
- 1 January 1985
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 48 (5) , 811-820
- https://doi.org/10.1080/09553008514551911
Abstract
Protein synthesis is normally required for G2-cell progression and for recovery from radiation-induced G2-arrest. In the presence of 5mm caffeine this requirement is alleviated, indicating that the mechanism responsible for G2 cell progression acutally remains intact in irradiated or protein synthesis inhibitor-treated cells. It is suggested that both radiation and cycloheximide-induced G2-arrest are not, therefore, passive consequences of cellular defects, but are rather, active cellular responses to the state of cellular integrity, implying the existence of G2 cell progression controls.Keywords
This publication has 18 references indexed in Scilit:
- Comparative analysis of caffeine and 3-aminobenzamide as DNA repair inhibitors in Synrian baby hamster kidney cellsMutation Research/DNA Repair Reports, 1984
- PCC technique reveals severe chromatin lesions and repair in G2-arrested cells after alpha irradiationExperimental Cell Research, 1983
- DIFFERENCES IN GROWTH REGULATION OF NORMAL AND TUMOR CELLS*Annals of the New York Academy of Sciences, 1982
- Mechanism by which caffeine potentiates lethality of nitrogen mustard.Proceedings of the National Academy of Sciences, 1982
- Radiosensitivity in ataxia-telangiectasia: a new explanation.Proceedings of the National Academy of Sciences, 1980
- Different drugs arrest cells at a number of distinct stages in G2Nature, 1975
- Use of the mitotic selection procedure for cell cycle analysis: Comparison between the X-ray and cycloheximide G2 markersExperimental Cell Research, 1972