PROLIFERATION RELATED PEPTIDES IN QUIESCENT AND REGENERATING RAT-LIVER

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 58  (2) , 119-129
Abstract
Aqueous extracts of resting (C) and 30 h regenerating (P) rat livers were partially purified by a combination of ion exchange, Sephadex and paper chromatographic techniques. A limited number of the semipurified chromatographic fractions inhibited or stimulated both DNA synthesis and cell proliferation, the effect being partially determined by C or P liver origin of the fractions. Biological activities were mediated by hepatic peptides of middle molecular size in the semipurified fractions. Regulation of hepatocyte proliferation might be under a dual control operating through an interplay of stimulatory and inhibitory peptides, the final outcome determined by their interaction.