EBV Gene Expression, EBNA Antibody Responses and EBV+Peripheral Blood Lymphocytes in Post-Transplant Lymphoproliferative Disease
- 1 January 1994
- journal article
- review article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 15 (1-2) , 9-16
- https://doi.org/10.3109/10428199409051672
Abstract
Epstein-Barr virus (EBV) is associated with the development of several B cell malignancies including Burkitt's lymphoma (BL), post-transplant lymphoproliferative disease (PTLD), and AIDS-related lymphomas. The latter two diseases result from EBV-driven B cell proliferation in the absence of normal immunosurveillance and as such, represent a heterogenous family of lymphoproliferative disorders. This article reviews studies on EBV gene expression and antibody development in PTLD and introduces recent information on the levels of EBV+ peripheral blood lymphocytes to discuss possible mechanisms of pathogenesis under varying conditions of immunosuppression.Keywords
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