Genetics of extended-spectrum beta-lactamases
- 1 January 1994
- journal article
- review article
- Published by Springer Nature in European Journal of Clinical Microbiology & Infectious Diseases
- Vol. 13 (1) , S2-S11
- https://doi.org/10.1007/bf02390679
Abstract
Bacteria have adapted to the introduction of aztreonam, cefotaxime, ceftazidime, ceftriaxone and other oxyimino-β-lactams by altering existing plasmid-mediated class A and class D β-lactamases so as to expand their spectrum of activity. In the TEM and SHV families of extended-spectrum β-lactamases, relative activity toward oxyimino-substrates increases with the number of amino acid substitutions but at the price of lowered intrinsic efficiency, so that compensatory up-promoter events are often associated with increased enzyme expression. Another new mechanism of resistance is the capture on plasmids of normally chromosomal genes fromEnterobacter cloacae, Citrobacter freundii orPseudomonas aeruginosa, which upon transfer can provideKlebsiella pneumoniae orEscherichia coli with resistance to α-methoxy-β-lactams, such as cefoxitin or cefotetan, as well as to oxyimino-β-lactams.Keywords
This publication has 69 references indexed in Scilit:
- Incidence of two virulence factors (aerobactin and mucoid phenotype) among 190 clinical isolates of Klebsiella pneumoniae producing extended-spectrum β-lactamaseFEMS Microbiology Letters, 1992
- Close amino acid sequence relationship between the new plasmid-mediated extended-spectrum β-lactamase MEN-1 and chromosomally encoded enzymes of Klebsiella oxytocaBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1992
- Two variants of transferrable extended-spectrum TEM-β-lactamase successively isolated from a clinical Escherichia coli isolateFEMS Microbiology Letters, 1992
- β‐lactamase TEM1 of E. coli Crystal structure determination at 2.5 Å resolutionFEBS Letters, 1992
- The frequency of extended-spectrum β-lactamases in isolates of Klebsiella pneumoniaeJournal of Antimicrobial Chemotherapy, 1992
- An IS1-like element is responsible for high-level synthesis of extended-spectrum -lactamase TEM-6 in EnterobacteriaceaeJournal of General Microbiology, 1991
- Different promoters of SHV-2 and SHV-2a -lactamase lead to diverse levels of cefotaxime resistance in their bacterial producersJournal of General Microbiology, 1991
- Chromosomally-mediated β-lactamases produced by Levinea amalonatica with activity against methoxyimino-cephalosporinsJournal of Antimicrobial Chemotherapy, 1991
- Dissemination in five French hospitals ofKlebsiella pneumoniae serotype K25 harbouring a new transferable enzymatic resistance to third generation cephalosporins and aztreonamEuropean Journal of Clinical Microbiology & Infectious Diseases, 1988
- Single amino acid substitution between SHV‐1 β‐lactamase and cefotaxime‐hydrolyzing SHV‐2 enzymeFEBS Letters, 1988