Evidence for linkage of murine beta 2-microglobulin to H-3 and Ly-4.
Open Access
- 1 April 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 126 (4) , 1644-1646
- https://doi.org/10.4049/jimmunol.126.4.1644
Abstract
Murine beta 2-microglobulin exists in 2 electrophoretically distinct forms; C57BL/6 mice possess the basic allele whereas BALB/c, CBA, AKR, and NZB possess the acidic allele. Mice heterozygous for beta 2-microglobulin express both alleles. Analysis of recombinant inbred mice suggests linkage of beta 2-microglobulin to H-2 or H-3. B10.C (28NX) mice (which possess the H-3c allele of BALB/c on a C57BL/10 background) possess the acid allele. Taken together, these results are consistent with the beta 2-microglobulin gene lying on chromosome 2, and being linked to H-3 and Ly-4.This publication has 1 reference indexed in Scilit:
- Ly-4.2: Doubts concerning its validity as a B-cell markerImmunogenetics, 1977