Mechanism of Action of the Sex Steroid Hormones

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Abstract
THE regulation of protein synthesis in the target tissue is undoubtedly the principal action of steroid hormones. The steroid molecule must be transported to the target tissue via the bloodstream and tissue fluids. It then penetrates the cell by simple or facilitated diffusion. On entry of the hormone into the cell, it is bound to a specific hormone receptor. This hormone-receptor complex is then transferred to the nucleus, in an "activated" form, where it is bound to the target-cell genome. Then, by a yet undefined process, the target cell responds by increased RNA synthesis followed by increased protein synthesis ( . . .