Biogenetic Effects of Opiates
- 1 January 1990
- journal article
- Published by Taylor & Francis in International Journal of the Addictions
- Vol. 25 (sup1) , 1-18
- https://doi.org/10.3109/10826089009067002
Abstract
Our laboratories have shown that opiate addicts have higher chromosome damage and sister chromatid exchange frequencies, and that these effects are more pronounced in the addicts when we employ enhanced culturing assays developed in our laboratory. We have also demonstrated that opiates diminish DNA repair capacity and reduce immunoresponsiveness as measured by T-cell E-rosetting and other assays. These interactions of opiates with T-lymphocytes may regulate cell metabolism and could thereby be responsible for the sensitivity of cells from opiate addicts to both genotoxic damage and immunological effects.Keywords
This publication has 38 references indexed in Scilit:
- Caffeine post-treatment causes a shift in the chromosome aberration types induced by mitomycin C, suggesting a caffeinesensitive mechanism of DNA repair in G2Mutagenesis, 1988
- Relationship between double strand break rejoining and G2 block formation in V79 cellsRadiation and Environmental Biophysics, 1986
- Effect of post-treatments with caffeine during G2 on the frequencies of chromosome-type aberrations produced by X-rays in human lymphocytes during G0 and G1Mutagenesis, 1986
- Relationships between chromosome damage, cell cycle delay and cell killing induced by bleomycin or X-raysMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1985
- Parallel increases in sister-chromatid exchanges at base level and with UV treatment in human opiate usersMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1983
- Induction of SCE by opium pyrolysates in CHO cells and human peripheral blood lymphocytesCarcinogenesis: Integrative Cancer Research, 1983
- Opium: A potential urinary bladder carcinogen in manCancer, 1979
- The Fetal Alcohol SyndromeNew England Journal of Medicine, 1978
- Intelligence, behavior, and dysmorphogenesis in the fetal alcohol syndrome: A report on 20 patientsThe Journal of Pediatrics, 1978
- DNA repair and frequency of X‐ray and u.v.‐light induced chromosome aberrations in leukocytes from patients with Down's syndromeAnnals of Human Genetics, 1976