Organic reactions of fluoro-oxy-compounds. Fluorination of griseofulvin
- 1 January 1972
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- Vol. 22, 2889-2891
- https://doi.org/10.1039/p19720002889
Abstract
Fluorination of griseofulvin (I) with trifluorofluoro-oxymethane affords 5-fluorogriseofulvin (2)(major product), 3′-fluorogriseofulvin (3), and 3′,5-difluorogriseofulvin (4). These results confirm the value of trifluorofluoro-oxy-methane as a selective electrophilic reagent for fluorination, comparable in its reactions to conventional reagents for direct halogenation.Keywords
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