Identification of BVT.2938 metabolites by LC/MS and LC/MS/MS after in vitro incubations with liver microsomes and hepatocytes
- 10 March 2004
- journal article
- Published by Elsevier in Journal of Pharmaceutical and Biomedical Analysis
- Vol. 34 (5) , 1079-1090
- https://doi.org/10.1016/j.jpba.2003.12.010
Abstract
No abstract availableKeywords
This publication has 9 references indexed in Scilit:
- Accelerating the Drug Optimization Process: Identification, Structure Elucidation, and Quantification of in Vivo Metabolites Using Stable Isotopes with LC/MSn and the Chemiluminescent Nitrogen DetectorAnalytical Chemistry, 2002
- Use of on‐line hydrogen/deuterium exchange to facilitate metabolite identificationRapid Communications in Mass Spectrometry, 2001
- The impact of accurate mass measurements using quadrupole/time-of-flight mass spectrometry on the characterisation and screeningAnalusis, 2000
- Usefulness of the hydrogen–deuterium exchange method in the study of drug metabolism using liquid chromatography-tandem mass spectrometryJournal of Pharmaceutical and Biomedical Analysis, 1998
- Simultaneous On-Line Characterization of Small Organic Molecules Derived from Combinatorial Libraries for Identity, Quantity, and Purity by Reversed-Phase HPLC with Chemiluminescent Nitrogen, UV, and Mass Spectrometric DetectionAnalytical Chemistry, 1998
- Novel oxidative pathway of para-substituted phenols in cytochrome P450 chemical model: Substituent elimination accompanying ipso-substitution by the oxygen atom of the active species1Tetrahedron Letters, 1995
- Identification of amperozide metabolites in urine from rats, rabbits, dogs and man by Frit‐FAB LC/MS using deuterated solvents to gain additional structural informationJournal of Mass Spectrometry, 1995
- Novel Metabolic Pathway of Arylethers by Cytochrome P450: Cleavage of the Oxygen-Aromatic Ring Bond Accompanying ipso-Substitution by the Oxygen-Atom of the Active Species in Cytochrome P450 Models and Cytochrome P450Archives of Biochemistry and Biophysics, 1994
- Preparative High-Performance Liquid Chromatography and Preparative Thin-Layer Chromatography Isolation of Tocainide Carbamoyl-Glucuronide: Structural Characterization by Gas Chromatography-Mass Spectrometry and Fast Atom Bombardment-Mass SpectrometryJournal of Pharmaceutical Sciences, 1990