Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics

2 August 1999

journal article
research article
Published by Wiley in Angewandte Chemie International Edition in English

Vol. 38 (15) , 2096-2152
https://doi.org/10.1002/(sici)1521-3773(19990802)38:15<2096::aid-anie2096>3.0.co;2-f

Abstract

The war against infectious bacteria is not over! Although vancomycin and glycopeptide antibiotics have provided a strong last line of defence against many drug-resistant bacteria, their overuse has given rise to more dangerous strains of bacteria. An understanding of the chemistry and biology of these highly complex glycopeptides are destined to play a crucial role in the discovery of new antibiotics.