MODIFICATION OF FAT AND CARBOHYDRATE-METABOLISM BY NEUROHYPOPHYSEAL HORMONES .1. EFFECT OF LYSINE-VASOPRESSIN ON NON-ESTERIFIED FATTY-ACID, GLUCOSE, TRIGLYCERIDE AND CHOLESTEROL LEVELS IN THE SERUM OF FEMALE RATS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 76  (3) , 315-325
Abstract
The effect of the s.c. lysine-vasopressin administration in doses of 0.625, 1.25, 2.5 and 5 IU/kg on serum non-esterified fatty acid, triglyceride, cholesterol and glucose levels in fed and fasting female rats was determined. All the doses, in both fed and fasting animals, caused a marked drop in non-esterified fatty acid levels about 15 min after starting the experiment. The only exceptions were fed females given doses 2.5 and 5 IU/kg, in which non-esterified fatty acid levels rose. Apart from animals given the smallest dose (0.625 IU/kg), glucose levels rose during the same interval. In the case of triglyceride levels, a dose of 0.625 IU/kg produced a decrease and the larger doses (1.25, 2.5 and 5 IU/kg) an increase in fed females. In fasting animals, triglyceride levels fell (statistically nonsignificantly) after doses of 0.625, 1.25 and 5 IU/kg, and rose after 2.5 IU/kg. The cholesterol level showed a temporary tendency to fall in most of the experiments.