ANTI-TUMOR ACTIVITY OF NORDITERPENOID DILACTONES IN PODOCARPUS PLANTS - STRUCTURE-ACTIVITY RELATIONSHIP ON INVITRO CYTOTOXICITY AGAINST YOSHIDA SARCOMA

  • 1 January 1979
    • journal article
    • research article
    • Vol. 70  (3) , 365-369
Abstract
The in vitro cytotoxicity [using rat Yoshida sarcoma cells] of norditerpenoid dilactones, isolated from Podocarpus plants, was determined. The unsaturated system on the B/C ring portion, the dienolide, or the epoxy-enolide moiety, was essential for the activity. The .gamma.-lactone group on the A/B ring portion was not.

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