Escherichia coli K-12 ferrous iron uptake mutants are impaired in their ability to colonize the mouse intestine
Open Access
- 15 March 1993
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 108 (1) , 111-115
- https://doi.org/10.1016/0378-1097(93)90496-o
Abstract
The streptomycin-treated mouse colonization model was used to investigate the role of the Fe2+ uptake system (Feo) of Escherichia coli K12 in the colonization of the mouse intestine. Mutants impaired in the uptake of Fe2+ ions were shown to be deficient also in their colonization ability. Both enterochelin-producing and enterochelin-nonproducing Escherichia coli feo mutants were unable to colonize the mouse intestine. These results demonstrated that Fe(II) is an essential source of iron for E. coli grown in the intestine.Keywords
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