Chromosomal radiosensitivity of ataxia telangiectasia cells at different cell cycle stages
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 52 (1) , 127-132
- https://doi.org/10.1007/bf00284606
Abstract
X-ray induced chromosomal aberrations in peripheral blood lymphocytes as well as in skin fibroblasts from ataxia telangiectasia patients, and from normal individuals were studied. At all stages of cell cycles—namely G0, G1, and G2, more aberrations were induced in AT cells than in normal cells. In addition, AT cells were sensitive to induction of chromosomal aberrations by tritium beta rays from incorporated radioactive thymidine. Possible reasons for the increased sensitivity of AT cells for induction of chromosomal aberrations by ionizing radiations are discussed.This publication has 12 references indexed in Scilit:
- Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observationsPublished by Elsevier ,2003
- Use of the 5-bromodeoxyuridine-labelling technique for exploring mechanisms involved in the formation of chromosomal aberrationsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1980
- Micrococcus luteus UV-endonuclease-sensitive sites and sister-chromatid exchanges in Chinese hamster ovary cellsMutation Research/Environmental Mutagenesis and Related Subjects, 1979
- The formation and recovery of two-break chromosome rearrangements from irradiated spermatozoa of Drosophila melanogasterMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- Excision of gamma-ray induced thymine lesions by preparations from ataxia telangiectasia fibroblastsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1977
- The timing of the restitution of chromosome breaks induced by X-rays in the mature sperm of Drosophila melanogasterMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1976
- Defective excision repair of γ-ray-damaged DNA in human (ataxia telangiectasia) fibroblastsNature, 1976
- Is chromatid-type damage in ataxia telangiectasia after irradiation at G0 a consequence of defective repair?Nature, 1976
- DNA strand breakage repair in ataxia telangiectasia fibroblast-like cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
- Chromosome breakage and mitotic inhibition induced by tritiated thymidine in root meristems of Vicia fabaExperimental Cell Research, 1961