Growth Curve of a Murine Leukemia Virus in Mice

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Abstract
The growth curves of a murine leukemogenic virus in plasma and spleen of BALB/c mice were similar to those of many non-neoplastic animal viruses. Virus disappeared rapidly after inoculation, and within 1 day little or no infective virus could be demonstrated. This was followed by a stationary or eclipse phase of approximately 4 days during which virus could not be recovered from the plasma or spleen. Beginning on the 5th day after inoculation, relatively large amounts of virus were present in both plasma and spleen and increased progressively until reaching a high plateau between the 7th and 14th days. There was no significant difference between the time required for demonstrable virus to appear in plasma or spleen. The spleen was the first tissue to show histologic evidence of disease. The presence of large amounts of virus in plasma before the development of leukemia is discussed in relation to the importance of non-neoplastic cells in the early synthesis of virus.

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