A novel strategy for regio- and stereo-control in glycosylation reactions: template-directed cyclo-glycosylation of monosaccharides

Abstract
Intramolecular glycosylation of several glucose derived glycosyl donor and acceptors that are linked, at O-6 and O-2 respectively, to a bifunctional spacer results in the regio- and stereo-controlled formation of 13-membered macrocyclic glycosides which can be easily converted to disaccharides.

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