Lignans with Inhibitory Activity against NFAT Transcription from Schisandra chinensis
- 31 January 2003
- journal article
- letter
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 69 (01) , 63-64
- https://doi.org/10.1055/s-2003-37024
Abstract
Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC50 : 1.33 ± 0.05 μM) and schisandrol A (IC50 : 1.34 ± 0.05 μM) showed higher activity than gomisin E (IC50 : 4.73 ± 0.09 μM), schisandrin A (IC50 : 7.23 ± 0.21 μM), schisandrin C (IC50 : 7.54 ± 0.22 μM), benzoylisogomisin O (IC50 : 11.06 ± 1.02 μM) and schisandrol B (IC50 : 16.37 ± 1.00 μM).Keywords
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