Effects of Arginine Vasotocin and Other Pharmacologically Active Substances on the Cardiovascular System of the Frog, Rana macrodon

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Abstract
Arginine vasotocin (8-arginine oxytocin) is a potent peripherally acting vasoconstrictor agent in the frog (Rana macrodon). This accounts for the pressor action of the peptide in the frog as arginine vasotocin appears to be without action on the heart. Reasons are given for the suggestion that 3-isoleucine in the ring of arginine vasotocin is important for the elicit at ion of a vasoconstrictor response. The effects or the lack of effects of other pharmacologically active agents is also described. The isolated heart of R. macrodon is remarkably sensitive to epinephrine (0.001 [mu]g produces a positive inotropic effect).