A COMPARISON OF THE EFFECTS OF GOITROGENS ON THYROID ACTIVITY IN TRITURUS VIRIDESCENS AND DESMOGNATHUS FUSCUS

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Abstract
Histological observations have indicated that during the summer the thyroid glands of Desmognathus fuscus fuscus are physiologically active but that those of Triturus viridescens viridescens are rather inactive. Both thiourea and potassium perchlorate inhibited thyroidal function in Desmognathus and produced in typical thyroidal hyperplasia. Thiourea permitted the uptake but not the binding of radioiodine in the thyroid; potassium perchlorate permitted neither. In Triturus, thiourea brought about only a slight hyperemia and potassium perchlorate produced no detectable histological change in the thyroid. Radiological measurements after the injection of 1131, however, indicated that the same physiological responses taking place in Desmognathus also occurred in Triturus but at a lower level of thyroidal function.