The Optimal Dosage in the Treatment of Hay Fever

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Abstract
Summary: The method of plotting the several doses to make a curve for the course of treatment in hay fever is new. By this method several observations can be made. In the majority of cases, the routine treatment in one season has but little effect upon the degree of hypersensitiveness at the outset of the next season, or upon the rate at which the tolerance to ragweed can be raised during the next season. Similar courses of treatment in different years are followed by similar end results. In those cases in which the courses of treatment have varied, it has been observed in about 20 per cent that a larger dosage was followed by a better end result. In at least 14 per cent of the cases, it has been possible to show that excessive dosage was responsible for the poor end results and that in many instances the result was much better when a smaller dose and a less vigorous course of treatment was employed. From this it is evident that success in the treatment demands a course of doses of a size and extent which is optimal for the particular patient. What this means so far as the underlying mechanism of hay fever is concerned, is a problem, the solving of which must wait upon the collection of data of another kind.

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