THE BLOCKING BY SPIROLACTONES OF THE ACTIONS OF ALDOSTERONE AND CORTISOL UPON THE HUMAN KIDNEY

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Abstract
SUMMARY The blocking effect of spironolactone ('Aldactone', Searle) has been tested against 100 mg. cortisol, and 0·25 mg. d-aldosterone, given intravenously. The sodium retention induced by either steroid is roughly halved by either a 300 or a 600 mg. dose of spironolactone. The high potassium excretion induced by cortisol is little if at all affected by spironolactone; the acute kaliuretic action of aldosterone is too small and inconstant to permit a clear assessment of blocking action. The implications of the apparent dissociation of the effects of cortisol upon sodium and upon potassium excretion are discussed.

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