Molecular Evolution of Viruses of the Family Filoviridae Based on 97 Whole-Genome Sequences
Open Access
- 1 March 2013
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 87 (5) , 2608-2616
- https://doi.org/10.1128/jvi.03118-12
Abstract
Viruses in the Ebolavirus and Marburgvirus genera (family Filoviridae) have been associated with large outbreaks of hemorrhagic fever in human and nonhuman primates. The first documented cases occurred in primates over 45 years ago, but the amount of virus genetic diversity detected within bat populations, which have recently been identified as potential reservoir hosts, suggests that the filoviruses are much older. Here, detailed Bayesian coalescent phylogenetic analyses are performed on 97 whole-genome sequences, 55 of which are newly reported, to comprehensively examine molecular evolutionary rates and estimate dates of common ancestry for viruses within the family Filoviridae. Molecular evolutionary rates for viruses belonging to different species range from 0.46 × 10−4 nucleotide substitutions/site/year for Sudan ebolavirus to 8.21 × 10−4 nucleotide substitutions/site/year for Reston ebolavirus. Most recent common ancestry can be traced back only within the last 50 years for Reston ebolavirus and Zaire ebolavirus species and suggests that viruses within these species may have undergone recent genetic bottlenecks. Viruses within Marburg marburgvirus and Sudan ebolavirus species can be traced back further and share most recent common ancestors approximately 700 and 850 years before the present, respectively. Examination of the whole family suggests that members of the Filoviridae, including the recently described Lloviu virus, shared a most recent common ancestor approximately 10,000 years ago. These data will be valuable for understanding the evolution of filoviruses in the context of natural history as new reservoir hosts are identified and, further, for determining mechanisms of emergence, pathogenicity, and the ongoing threat to public health.Keywords
This publication has 47 references indexed in Scilit:
- Emergence of Divergent Zaire Ebola Virus Strains in Democratic Republic of the Congo in 2007 and 2008The Journal of Infectious Diseases, 2011
- Purifying Selection Can Obscure the Ancient Age of Viral LineagesMolecular Biology and Evolution, 2011
- Evolutionary maintenance of filovirus-like genes in bat genomesBMC Ecology and Evolution, 2011
- Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviationsArchiv für die gesamte Virusforschung, 2010
- Filoviruses are ancient and integrated into mammalian genomesBMC Ecology and Evolution, 2010
- Many-core algorithms for statistical phylogeneticsBioinformatics, 2009
- BEAST: Bayesian evolutionary analysis by sampling treesBMC Ecology and Evolution, 2007
- Isolates of Zaire ebolavirus from wild apes reveal genetic lineage and recombinantsProceedings of the National Academy of Sciences, 2007
- Marburgvirus Genomics and Association with a Large Hemorrhagic Fever Outbreak in AngolaJournal of Virology, 2006
- MAFFT version 5: improvement in accuracy of multiple sequence alignmentNucleic Acids Research, 2005