Characterization by 2D-NMR and chemical properties of (20Z)-3-methoxy-17-[2-(triphenylstannyl)vinyl]estra-1,3,5(10)-trien-17β-ol

Publisher Website
Google Scholar
Abstract
The complete solution structure and conformation of the title compound were determined by 2D proton detected 1H–13C HMQC-RELAY and 2D-NOESY build-up experiments. The assignment of the low field resonances of the quaternary carbon atoms was achieved by 1D–13C NMR with selective decoupling of the high field protons. Proton detected 1H–119Sn HMBC 1D and 2D NMR spectroscopy enables the observation of a very weak coupling between the hydroxy proton of the steroid moiety and the 119Sn nucleus. These proton detected experiments as well as 13C and 119Sn SIMPLE NMR provide evidence for a HO → Sn coordination to occur in solution.