Distribution of GABA Receptors in the Rat Cerebellum
- 1 September 1980
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 35 (3) , 739-742
- https://doi.org/10.1111/j.1471-4159.1980.tb03715.x
Abstract
GABA receptor distribution in the cerebellum is not homogeneous. In comparison with detergent-treated membranes from the whole tissue the number of [3H]muscimol binding sites/mg protein (Bmax) is about doubled in preparations enriched in large fragments of the cerebellar glomeruli, and it is about 1/3 in the dissected deep nuclei. The apparent affinity (Kd) is similar in the different preparations. Heterogeneity may exist in cerebellar GABA receptors and/or their control.This publication has 21 references indexed in Scilit:
- (–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptorNature, 1980
- Regional distribution of Na+-independent GABA and benzodiazepine binding sites in rat CNSBrain Research, 1979
- Autoradiographic localisation of benzodiazepine receptors in the brains of humans and animalsNature, 1979
- γ‐AMINOBUTYRTC ACID RECEPTORS IN CEREBELLAR MEMBRANES OF RAT BRAIN AFTER A TREATMENT WITH TRITON X‐1001Journal of Neurochemistry, 1979
- An endogenous protein modulates the affinity of GABA and benzodiazepine receptors in rat brainNature, 1978
- Localization of gamma‐aminobutyric acid receptor binding in the mammalian cerebellum high levels in granule layer and depletion in agranular cerebella of mutant miceJournal of Neurochemistry, 1978
- Endogenous inhibitor of GABA binding in mammalian brainLife Sciences, 1978
- A rapid procedure for obtaining a preparation of large fragments of the cerebellar glomeruli in high purityJournal of Neurochemistry, 1975
- How selective is high affinity uptake of GABA into inhibitory nerve terminals?Nature, 1974
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949