An efficient route to the tropane alkaloids
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- Vol. 23 (7) , 787-790
- https://doi.org/10.1039/p19920000787
Abstract
We describe the use of diethylzinc in conjunction with polybromo ketones for the production of oxyallyls, and the interception of these intermediates by furans and methyl pyrrole-N-carboxylate. This methodology allows the production of gramme quantities of tropane alkaloids, and 2-substituted 8-oxabicyclo[3.2.1 ]oct-6-en-3-ones that have been either difficult or impossible to prepare.Keywords
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