Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo
- 1 May 2000
- journal article
- nonviral transfer-technology
- Published by Springer Nature in Gene Therapy
- Vol. 7 (10) , 826-829
- https://doi.org/10.1038/sj.gt.3301173
Abstract
Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated.Keywords
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