DISSOLUTION OF STRUVITE URINARY STONES - EXPERIMENTAL STUDIES INVITRO

  • 1 January 1976
    • journal article
    • research article
    • Vol. 13  (5) , 351-353
Abstract
Struvite crystals were previously shown to form primarily as a result of urease-induced alkalinity and supersaturation. In vitro perfusion of struvite crystals with undersaturated urine caused crystal dissolution. Complete dissolution of human struvite urinary stones was demonstrated during 6 wk of perfusion in vitro with undersaturated human urine. Human hydroxyapatite stones perfused similarly underwent only slight dissolution. A glycoprotein precipitated as the stones dissolved; the pathogenic significance of the glycoprotein is unknown.

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