On the mode of action of pseudomonic acid: Inhibition of protein synthesis in Staphylococcus aureus.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (4) , 330-335
- https://doi.org/10.7164/antibiotics.31.330
Abstract
The effect of the antibiotic, pseudomonic acid, on the major metabolic processes in S. aureus was studied. The primary effect of low concentrations of the antibiotic, leading to bacteriostasis, is inhibition of protein synthesis. Pseudomonic acid also severely inhibits RNA synthesis which can be prevented by chloramphenicol treatment. DNA and cell wall peptidoglycan synthesis are inhibited to a lesser extent and interference with these processes is considered to be a secondary effect. Oxidative phosphorylation as measured by ATP levels was not inhibited.This publication has 2 references indexed in Scilit:
- Pseudomonic acid. Part 1. The structure of pseudomonic acid A, a novel antibiotic produced by Pseudomonas fluorescensJournal of the Chemical Society, Perkin Transactions 1, 1977
- A Fractionation Procedure for Studies of the Synthesis of Cell-Wall Mucopeptide and of Other Polymers in Cells of Staphylococcus aureusJournal of General Microbiology, 1960