The nature of migraine: do we need to invoke slow neurochemical processes?

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Abstract
This chapter asks: What is migraine? The word ‘migraine’ needs clarifying because it can be used in two senses: clinical attacks and the underlying migraine processes. This chapter describes the clinical phenomena of migraine (first in outline and then in detail), followed by the life-cycle of migraine in individuals, and ends with some implications of clinical migraine on possible mechanisms. The chapter tries to define migraine more strictly, the novel feature of this definition being that it includes timing, which has been incorporated in the International Headache Society's (IHS) Classification. This chapter describes five phases of migraine attack.

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