Effects of Renin on Excretion of Sodium, Chloride and Water in the Rat

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Abstract
In the rat, renin admn. increases the urinary volume and concomitantly increases the Na and chloride concns. of the urine to levels exceeding those in the serum. There is no increase in the serum Na or chloride concns. as a result of renin admn. Renin does not cause an increase in the rate of glomerular filtration as detd. by the clearance of exogenous creatinine. In rats previously given high salt loads, renin causes a fall in the Na and chloride concns. in the urine toward the levels found in the serum. The results indicate that in the rat, renin impairs the ability of the renal tubule differentially to reabsorb Na, chloride, and water.

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