The Purine Nucleotide Cycle Revised

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Abstract
This review is restricted to the operation of the purine cycle in mammalian muscle. A previous review provided a summary of early evidence for the operation of the cycle and of various functions proposed for the cycle. It also provided a brief history of work on ammonia production by muscle and other tissues and of the discovery of the enzymes of the purine nucleotide cycle (36). Recent reviews on the purine nucleotide cycle include those of Terjung et al. (78) and van Waarde (86).

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