Polymorphic variation in the amount of sialic acid attached to bovine transferrin

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Abstract
Family studies are presented which support the hypothesis of polymorphism in the process controlling sialic acid binding to bovine transferrin (Tfs) which modifies its phenotype as seen in starch gel electrophoresis. This polymorphism is apparently controlled by a locus Tfs with 2 alleles Tfs A and Tfs a. Tfs a/a animals have the abnormal phenotype with the 2 faster bands of the 4 bands of a normal transferrin allele being virtually absent. Tfs A/a and Tfs A/A are phenotypically normal. Limited evidence is presented which suggests that the Tf and Tfs loci are not linked.