The fate of mouse spleen cells transplanted into homologous and F1 hybrid hosts.

  • 1 April 1959
    • journal article
    • Vol. 2  (2) , 170-81
Abstract
The fate of antibody-producing mouse spleen cells transplanted intraperitoneally into isologous, homologous and F1 hybrid mice has been investigated by the use of donors hyperimmunized against sheep or human red cells. Survival of the transplanted cells was indicated by a rising titre of haemagglutinins in the host or by a secondary response to challenge with a critical dose of red cells. This dose was sufficient to evoke a vigorous secondary response in immunized mice but only a weak primary response in unimmunized mice.