Minor‐groove width and accessibility in B‐DNA drug and protein complexes
- 17 February 1992
- journal article
- Published by Wiley in FEBS Letters
- Vol. 298 (1) , 97-99
- https://doi.org/10.1016/0014-5793(92)80030-k
Abstract
A new definition is presented for minor-groove width in double-helical B-DNA structures. This uses interstrand H4' ... H5' rather than P ... P distances. It is shown by examination of various oligonucleotide crystal structures that these H4' ... H5' distances are a sensitive measure of minor-groove drug and protein binding, since these hydrogen atoms are in direct non-bonded contact with such bound ligands.Keywords
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