THE RELATIONSHIP OF SEX STEROIDS TO URIC ACID LEVELS IN PLASMA AND URINE

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Abstract
The effect of endogenous and exogenously administered estrogens, androgens and progesterone on plasma and urinary uric acid and uric acid clearance was studied in a total of 65 healthy volunteers, including normal menstruating and post-menopausal women, girls with primary amenorrhaea and adult male subjects. A serial study throughout a full cycle in 3 women showed an inverse relationship between plasma uric acid levels and endogenous estrogens. Administration of conjugated and synthetic estrogens decreased plasma uric acid concentration through a uricosuric effect in most subjects of both sexes. Testosterone propionate increased plasma uric acid levels in post-menopausal women, while endogenous testosterone changes due to Leydig cell stimulation produced no definite effect in male subjects. Administration of a progesterone preparation produced an effect similar to that of estrogens in post-menopausal women. The view that sex steroids play a significant part in uric acid regulation in biological fluids of both sexes was supported.

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