Renin-activation by kallikrein: evidence for alkaline-activation of plasma renin
- 1 December 1979
- journal article
- research article
- Published by Wiley in European Journal of Clinical Investigation
- Vol. 9 (6) , 447-449
- https://doi.org/10.1111/j.1365-2362.1979.tb00911.x
Abstract
Porcine pancreatic kallikrein leads to a significant activation of human plasma renin when incubated at pH 8.2. Endogenous activation of plasma renin can be seen by incubation of plasmas at the same pH. Both endogenous alkaline- and kallikrein-activation of plasma renin can be inhibited by aprotinin. Both kallikrein- and endogenous alkaline-activation of plasma renin are significantly correlated to cryo- and acid-activation. Kallikrein- and endogenous alkaline-activation come close to the in vivo activation process.Keywords
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