NATURE OF CLOTTING AND FIBRINOLYTIC-ACTIVITIES OF BACTEROIDES MELANINOGENICUS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 240  (1) , 106-111
Abstract
From the supernatant of B. melaninogenicus ssp. asaccharolyticus culture, a protein fraction was isolated by ethanol precipitation. The fraction was tested for presence of clotting and fibrinolytic activities by application of quantitative techniques and specific substrates for measurement of prothrombin and plasminogen activation and collagenase and elastase activity. Apparently the ability of B. melaninogenicus ssp. asaccharolyticus extracellular factors to clot fibrinogen and activate plasminogen is due to a limited proteolysis by the proteolytic enzymes produced by this microorganism and not to the existence of specific B. melaninogenicus coagulase or plasminogen activator. The observations suggest some biological role of bacterial proteases in infection in humans.