Regional extravascular and interstitial lung water in normal dogs

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Abstract
The regional distribution of pulmonary extravascular and iterstitial water was measured to examine the possibility that regional differences in microvascular pressure or tissue stress may cause regional differences in lung water. Chloralose-anesthetized dogs were placed in an upright (n = 6) or supine (n = 7) position for 180 min. 51Cr-labeled EDTA was injected to equilibrate to the extracellular space and 125I-labeled albumin to equilibrate with plasma. At the end of the experiment, the lungs were removed, passively drained of blood and inflated before rapid freezing. Lungs were divided into horizontal slices, and extravascular, interstitial, and plasma water, red cell volume and dry lung weight were determined for each slice. Regional extravascular and interstitial water were constant throughout the lungs in both groups; there were no significant differences between upright and supine dogs. There were no significant differences in hematocrit between slices. Gravity and body position have no measurable effect on either the total size of the extravascular and interstitial compartments or their regional distribution.

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