The Formation of Polymer Vesicles or “Peptosomes” by Polybutadiene-block-poly(l-glutamate)s in Dilute Aqueous Solution
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- 1 February 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (8) , 1658-1663
- https://doi.org/10.1021/ja012091l
Abstract
Polybutadiene-block-poly(l-glutamate) copolymers were made by anionic polymerization and subsequent ring-opening polymerization of N-carboxyanhydrides and were characterized by NMR, IR, SEC, and circular dichroism. These polymers, when appropriately designed, form so-called “polymersomes” or “peptosomes”, vesicles composed of modified protein units. The size and structure of the vesicles are determined by dynamic light scattering, small-angle neutron scattering, and freeze-fracture electron microscopy. It is also shown that the size of the peptosomes does not depend on the pH; that is, the solvating peptide units can perform a helix−coil transition without serious changes of the vesicle morphology.Keywords
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