The effects of guanine and cytosine variation on dinucleotide frequency and amino acid composition in the human genome
- 1 August 1988
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 27 (4) , 321-325
- https://doi.org/10.1007/bf02101194
Abstract
One hundred twelve human DNA sequences were analyzed with respect to dinucleotide frequency and amino acid composition. The variation in guanine and cytosine (G+C) content revealed: (1) at 2–3 and 3-1 doublet positions CG discrimination is attenuated at high G+C, but TA disfavor is enhanced, and (2) several amino acids are subject to G+C change. These findings have been reported in part for collections of sequences from various species. The present study confirms that in a single organism-the human-the G+C effects do exist. Aspects of the argument that connects G+C with protein thermal stability are also discussed.This publication has 39 references indexed in Scilit:
- Compositional constraints and genome evolutionJournal of Molecular Evolution, 1986
- Silent nucleotide substitutions and G+C content of some mitochondrial and bacterial genesJournal of Molecular Evolution, 1986
- The Mosaic Genome of Warm-Blooded VertebratesScience, 1985
- Replication Timing of Genes and Middle Repetitive SequencesScience, 1984
- Eukaryotic dinucleotide preference rules and their implications for degenerate codon usageJournal of Molecular Biology, 1981
- DNA methylation and the frequency of CpG in animal DNANucleic Acids Research, 1980
- Doublet frequency analysis of fractionated vertebrate nuclear DNAJournal of Molecular Biology, 1976
- Intracellular Protein Degradation in Mammalian and Bacterial Cells: Part 2Annual Review of Biochemistry, 1976
- A simplified representation of protein conformations for rapid simulation of protein foldingJournal of Molecular Biology, 1976
- Intracellular Protein Degradation in Mammalian and Bacterial CellsAnnual Review of Biochemistry, 1974